Nicholas P Farrell Selected Research

BBR3610

2/2011	Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma.
12/2010	The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells.
9/2007	Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling.
7/2006	Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma.

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Nicholas P Farrell Research Topics

Disease

19	Neoplasms (Cancer) 01/2022 - 12/2004
7	Carcinoma (Carcinomatosis) 05/2018 - 06/2007
5	Glioma (Gliomas) 02/2016 - 01/2006
4	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2018
3	Ovarian Neoplasms (Ovarian Cancer) 08/2015 - 06/2007
2	Triple Negative Breast Neoplasms 01/2022 - 11/2020
2	Brain Neoplasms (Brain Tumor) 02/2016 - 02/2011
2	Glioblastoma (Glioblastoma Multiforme) 02/2016 - 02/2011
2	Melanoma (Melanoma, Malignant) 01/2013 - 02/2010
2	Colonic Neoplasms (Colon Cancer) 01/2012 - 09/2007
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Infections 05/2021
1	Virus Diseases (Viral Diseases) 05/2021
1	Leukemia 11/2020
1	Pathologic Processes 01/2018
1	Inflammation (Inflammations) 01/2018
1	Osteosarcoma (Osteogenic Sarcoma) 06/2012
1	Neuralgia (Stump Neuralgia) 01/2012
1	Prostatic Neoplasms (Prostate Cancer) 01/2012
1	Colorectal Neoplasms (Colorectal Cancer) 01/2012
1	Carcinogenesis 02/2011

Drug/Important Bio-Agent (IBA)

16	PlatinumIBA 05/2021 - 12/2004
13	Cisplatin (Platino)FDA LinkGeneric 11/2020 - 07/2006
7	Pharmaceutical PreparationsIBA 06/2019 - 01/2006
4	BBR3610IBA 02/2011 - 07/2006
3	BBR 3464 (BBR3464)IBA 01/2016 - 07/2006
3	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 06/2007
3	Platinum Compounds (Compounds, Platinum)IBA 02/2011 - 12/2004
2	Carboplatin (JM8)FDA LinkGeneric 01/2022 - 08/2015
2	triplatinNCIBA 05/2021 - 01/2021
2	MetalsIBA 01/2019 - 02/2011
2	GlycosaminoglycansIBA 01/2019 - 01/2018
2	IonsIBA 01/2019 - 02/2011
2	heparanaseIBA 05/2018 - 01/2018
2	EnzymesIBA 05/2018 - 01/2018
2	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 05/2018 - 01/2018
2	LigandsIBA 01/2018 - 01/2017
2	Heparitin Sulfate (Heparan Sulfate)IBA 01/2018 - 01/2017
2	Antidepressive Agents (Antidepressants)IBA 01/2014 - 01/2012
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 06/2012 - 01/2012
2	DNA AdductsIBA 06/2011 - 01/2010
2	Phosphotransferases (Kinase)IBA 02/2010 - 09/2007
1	A73025IBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	Antiviral Agents (Antivirals)IBA 05/2021
1	NaphthoquinonesIBA 11/2020
1	phosphine (phosphane)IBA 11/2020
1	tesmilifene (DPPE)IBA 11/2020
1	Oncogene Proteins (Oncogene Protein)IBA 06/2019
1	Proteins (Proteins, Gene)FDA Link 01/2018
1	CarbohydratesIBA 01/2018
1	Heparin (Liquaemin)FDA LinkGeneric 01/2018
1	Sulfates (Sulfates, Inorganic)IBA 01/2017
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2017
1	Ribosomal Proteins (Ribosomal Protein)IBA 01/2017
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2017
1	Sorafenib (BAY 43-9006)FDA Link 02/2016
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 02/2016
1	Sepharose (Agarose)IBA 02/2016
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 02/2016
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 02/2016
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 02/2016
1	CateninsIBA 02/2016
1	transplatinIBA 01/2016
1	Paclitaxel (Taxol)FDA LinkGeneric 08/2015
1	Docetaxel (Taxotere)FDA Link 08/2015
1	RNA Precursors (Precursor, mRNA)IBA 01/2015
1	trioctyl phosphine oxide (TOPO)IBA 01/2013
1	Mannich BasesIBA 01/2013
1	Peptides (Polypeptides)IBA 06/2012
1	Desipramine (Pertofrane)FDA LinkGeneric 01/2012
1	Antineoplastic Agents (Antineoplastics)IBA 01/2012
1	PX-866IBA 02/2011
1	Cytotoxins (Cytolysins)IBA 02/2011
1	RNA (Ribonucleic Acid)IBA 02/2011
1	SpermineIBA 12/2010
1	InterleukinsIBA 02/2010
1	CytokinesIBA 02/2010
1	Protein Kinases (Protein Kinase)IBA 02/2010
1	SpermidineIBA 04/2008
1	Inositol (Myoinositol)IBA 09/2007
1	ErbB Receptors (EGF Receptor)IBA 09/2007
1	hydroxide ionIBA 06/2007
1	AminesIBA 06/2007
1	quinolineIBA 06/2007
1	isoquinolineIBA 06/2007
1	pyridineIBA 06/2007
1	BBR 3571IBA 07/2006
1	ProteomeIBA 01/2006

Therapy/Procedure

3	Drug Therapy (Chemotherapy) 01/2022 - 12/2004
3	Therapeutics 02/2016 - 02/2011
1	Neoadjuvant Therapy 01/2022
1	Precision Medicine 01/2022